All these compounds are reported to have beneficial role in diabetes as well as to attenuate diabetes induced complications via different ways: beta-sitosterol improves glucose uptake and lipid metabolism [60], [61] and alpha glucosidase inhibition [62]; phloretin enhances glucose uptake [63], [64] and oleanolic acid improves insulin response [65], [66] and possesses alpha glucosidase inhibitory property [67]. The gene discussed is INS; the disease is diabetes mellitus.