GPT and Decreased total leukocyte count: There were no statistically significant differences between the two groups of patients in terms of age, daily dose of TMP/SMX, serostatus of hepatitis B or C virus, plasma HIV RNA load, alcohol ingestion, smoking, use of steroids, baseline total bilirubin, ALT, AST, and LDH level, mortality, development of skin rash, nausea or vomiting, and leukopenia.