Extensive literature on the interactions of CRT with C1q has been reported in human emphasizing its important role in the inflammatory processes associated with vascular or atherosclerotic lesions, autoimmune diseases [16], [38]–[40] while in case of parasites (T. Cruzi, H. contortous, N. americanus) it is responsible for establishment of infection by preventing host immune response [20], [41]–[43]. The gene discussed is CALR; the disease is autoimmune disease.