AKT1 and diabetes mellitus: Thus, to further assess these mechanisms of liraglutide in skeletal muscle, we examined PI3K/Akt signaling pathway, a classic pathway which was vital for diabetes study, after He et al. studied diabetic cardiomyopathy [21], Cao et al. studied glucose homeostasis [22], and Zhang et al. discovered the injury of high glucose through the PI3K/Akt pathway [23].