In Pompe disease, the CHO-produced recombinant human GAA (rhGAA; alglucosidase alpha, Myozyme®, Genzyme Corporation, Framingham, MA) is a 110 kDa precursor containing M6P groups that enable the enzyme to bind the receptor on the cell surface. This evidence concerns the gene GAA and Glycogen storage disease due to acid maltase deficiency.