Pompe disease, also known as glycogen storage disease type II (GSDII) or “acid maltase deficiency”, is caused by the absence or deficiency of acid alpha-glucosidase (GAA), a lysosomal enzyme that is responsible for the cleavage of the α-1,4- and α-1,6-glycosidic bonds of glycogen to glucose. Here, GAA is linked to glycogen storage disease II.