PDK1 and triple-negative breast carcinoma: Conversely, PGR (Cancello et al. 2013; Prat et al. 2013), PDK1 (Gagliardi et al. 2012), and PEA15 are associated with Luminal A. Interestingly, in triple-negative breast cancer and ovarian cell lines, increasing PEA15 levels was shown to have an antitumor effect (Bartholomeusz et al. 2006, 2010).