FOXO3 and scrapie: Consistent with the lower expression levels of DLK (two-tailed paired ratio t-test; P = 0.0182), JNK2 (P = 0.0063), and MST1 (P = 0.0095), FOXO3 levels were also significantly lower (P < 0.0001) in the brainstem-cerebellum of scrapie- than of mock-infected mice at 130 dpi (Figure 7).