Mitogen-activated protein kinase 12 (p38γ), ribosomal S6 kinase 1 (RSK1), v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (Lyn), and CaMK4β, which clustered together because they were expressed to similarly higher levels in scrapie- than in mock-infected mice at 70 dpi, are all involved in an N-methyl-D-aspartate receptor (NMDAR)-regulated CaMK4β signaling pathway that promotes neuronal survival (Figure 4B, i). This evidence concerns the gene MAPK12 and scrapie.