Active MST1 (P-T183) is cleaved by active (cleaved) caspase-3[57–60], the levels of which are elevated in scrapie-infected mice (before the accumulation of PrPres) and in cultured neurons or neuroblastoma cells exposed to PrP106-126 or PrPSc[89–92]. Here, CASP3 is linked to scrapie.