Levels of cleaved MST1 were significantly higher at 130 dpi in all brain regions (brainstem-cerebellum, P = 0.0452; subcortical region, P = 0.0237; cortical region, P = 0.0243), whereas activated JNK levels were similar in scrapie- and mock-infected mice at this time (Figure 8). The gene discussed is MST1; the disease is scrapie.