Consistent with the higher levels of RSK1, Lyn, p38γ, and CaMK4β in the brainstem-cerebellum of scrapie-infected mice at 70 dpi, the levels of nNOS and CREB were also higher at this time (two-tail paired ratio t-test; nNOS, P = 0.0434; CREB, P = 0.0341) (Figure 5). Here, CREB1 is linked to scrapie.