MAPK1 and scrapie: The levels of activated p38 (P-T180/T182) were significantly higher in scrapie-infected than in mock-infected mice at 70 and 90 dpi (brainstem-cerebellum P = 0.0225 [90 dpi]; subcortical region P = 0.0106 [70 dpi]; cortical region P = 0.0014 [70 dpi]) but also at 110 and 130 dpi (brainstem-cerebellum P = 0.0465 [110 dpi]; cortical region P = 0.0116 [130 dpi]) (Figure 6).