CREB1 and scrapie: Their levels were significantly higher in the brainstem-cerebellum of scrapie-infected than of mock-infected mice at 70 and 90 dpi (two-tail paired ratio t-test; CaMK4β P = 0.0256 [70 dpi], 0.0248 [90 dpi]; CREB P = 0.0197 [70 dpi], 0.0086 [90 dpi]) (Figure 6).