GRM1 is associated with a number of neurological diseases including schizophrenia and depression (Kohara et al., 2008) and is significantly increased +1.83 fold, and HCN2, which contributes to spontaneous brain rhythmic activity, and dysfunction is associated with epilepsy (Bender et al., 2003), is increased +2.7 fold. The gene discussed is HCN2; the disease is major depressive disorder.