JUNB and FOSL1 are proto-oncogenes that are components of the AP-1 transcription complex (Kouzarides and Ziff, 1989) and have been reported to be part of a long feedback loop in ovarian cancer (Stelniec-Klotz et al., 2012); EGR1 is a regulator of tumour suppressor genes and an oncogene itself (Baron et al., 2005); and the TFs of the C/EBP family have been described as both tumour promoters and suppressors (Nerlov, 2007). The gene discussed is EGR1; the disease is ovarian carcinoma.