Tumor cells with increased activity of the detoxifying enzyme aldehyde dehydrogenase (ALDH) are considered as putative breast CSCs, due to their self-renewal capacity as shown by serial passages in Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) mice and their ability to regenerate the cellular heterogeneity of the initial tumor [9]. Here, LDHA is linked to neoplasm.