MAPT and Hypoglycemia: Shortly after permanent MCAO, i.e., at 1 hour (Figure 1 and Supplementary Table 1), highly elevated creatine and reduced phosphocreatine are observed, and signifies energy failure in global ischemia26 and hypoglycemia.27 A sudden change in relative ion concentrations after ischemia would explain the observed osmoregulation dysfunction,25 for example, the significant reduction of Tau and myo-inositol, described in Figure 1 and Supplementary Table 1.