In addition, T-cell specific over-expression of Bcl-2, which can inhibit both Bim and Puma (Chen et al., 2005), does not lead to autoimmunity (Sentman et al., 1991; Linette et al., 1995), suggesting that a defect in T cells alone may be insufficient to cause disease. This evidence concerns the gene BCL2 and Autoimmunity.