In the experimental autoimmune encephalomyelitis model (EAE) of multiple sclerosis, intranasal (i.n.)administration of a soluble myelin basic protein (MBP) peptide induces tolerance15, 16, 17 through the induction of IL-10-secreting CD4+ FoxP3- T cells16, 17, 18, 19. This evidence concerns the gene MBP and experimental autoimmune encephalomyelitis.