Specific markers are expressed and reported in bone marrow and peripheral blood depending on the type of disease; for example, Nkx-1 and Pdx-1 are upregulated in response to pancreatic damage [44], germ cell-specific markers are expressed when gonadal function is compromised by treatment with busulphan in ovary [45] as well as in testis [46], and neural markers are elevated in the case of stroke [47]. Here, PDX1 is linked to Stroke.