miR-10b [35], miR-206 [36] and miR-103/107 [37] have been characterized as oncomiRs as their overexpression in esophageal and colorectal cancer correlates with enhanced proliferative and/or metastatic phenotypes that result from the downregulation of the tumor suppressor KLF4 [35]–[37]. This evidence concerns the gene KLF4 and colorectal cancer.