MYH7 and cardiac hypertrophy: To investigate the mechanism(s) involved in left ventricular (LV) gene expression re-programming during cardiac hypertrophy and failure, we analyzed a well-known murine model of cardiac pressure overload induced by transverse aortic constriction (TAC) [4] at two time points: one week (1w) or eight weeks (8w) after surgery, and we focused our study on two representative genes, Atp2a2 and Myh7, whose reprogramming in cardiac hypertrophy and failure is well established [1].