THOP1 and metastatic malignant neoplasm in the lymph nodes: The results of multivariate Cox regression analysis showed that the significant prognostic effect of positive lymph node metastasis (P = 0.653, Table 3) and advanced TNM stage (P = 0.218, Table 3) observed on univariate analysis disappeared, and only low THOP1 expression retained its significance as an independent prognostic factor for unfavorable overall survival (P = 0.021, Table 3).