EGFR and autosomal dominant polycystic kidney disease: In addition to altered Hedgehog signaling, aberrant expression and signaling from the tyrosine kinase epidermal growth factor receptor (EGFR) is implicated in both craniofacial disorders and ADPKD [15]–[17], and in primary cilia of renal epithelia, EGFR interacts with and regulates PC2 ion channel activity [7].