Plasma PCSK9 levels were markedly elevated in 45 individuals with acute MI (363.5±140.0 ng/ml) compared to 398 CAD cases without MI (302.0±91.3 ng/ml, p = 0.004), adjusted for age at consent, male sex, BMI, smoking, and antihypertensive meds (Figure 2). The gene discussed is PCSK9; the disease is myocardial infarction.