For example, FBxw7/Archipelago, a component of the SCF ubiquitin ligase complex that target cyclinE for degradation is mutated or inactivated in a variety of cancers (Moberg et al, 2001; Strohmaier et al, 2001; Mao et al, 2004; Iwatsuki et al, 2010). The gene discussed is FBXW7; the disease is cancer.