Autosomal recessive congenital ichthyosis (ARCI) is caused by mutation in the genes, encoding keratinocyte transglutaminase (TGM1; 190195) on chromosome 14q11.2, ALOX12B gene (OMIM603741) on chromosome 17p13.1, ALOXE3 gene (OMIM607206) on chromosome 17p13.1, ABCA12 gene (OMIM607800) on chromosome 2q35, CYP4F22 gene (OMIM611495) on chromosome 19p13, NIPAL4 gene (ichthyin; OMIM609383) on chromosome 5q33, LIPN gene (OMIM613924) on chromosome 10q23, CERS3 gene (OMIM615276) on chromosome 15q26, and PNPLA1 gene (OMIM612121) on chromosome 6p21. This evidence concerns the gene LIPN and autosomal recessive congenital ichthyosis.