P2RY12 and myeloid sarcoma: Although with different intensities, they not only recognize the receptor specifically on myelinated fibers of organotypic cultures (Figure 2(c)), tissues slices from rat striatum or cerebellum (Figure 3) and human cerebral cortex, but also furthermore highlight the reduction of P2Y12 signal that occurs for instance in MS tissue (Figure 5) in correlation to the extent of demyelination found in all types of grey matter cortical plaques (I–III) and subcortical white matter [13].