A second implication that emerges from our results is that the morphological metamorphosis that microglia undergo under neuroinflammatory conditions as those triggered during ALS and MS, can be remarkably highlighted by the progressive reduction of P2Y12 immunostaining obtained with c-ter antibody that reacts, also in this case, exclusively with multibranched microglia still present in the tissue (Figures 4 and 6). Here, P2RY12 is linked to myeloid sarcoma.