In order to provide wide ranging comparative analysis of P2Y12 expression particularly in microglia and oligodendrocytes under neuroinflammatory conditions, we performed immunofluorescence and confocal analysis of receptor expression in primary cortical and organotypic cerebellar cultures, in tissue slices from rat striatum and cerebellum, in spinal cord sections from symptomatic and end stage SOD1-G93A ALS mouse model, finally in autoptic cortical tissue from progressive MS donors. This evidence concerns the gene P2RY12 and myeloid sarcoma.