IGHE and chronic asthma: Mice used in this model exhibited several symptoms that were similar to those observed in humans with chronic asthma, including high allergen-specific IgE levels; pulmonary eosinophilia and AHR; and increased IL-5, IL-13, IL-17, and IFN-γ levels in BALF; increased co-stimulatory B7.2 expression on BALF cells; and features of airway remodeling, including collagen deposition and goblet cell hyperplasia [17, 18].