Although it is still unclear whether CLL is a germinal center-derived malignancy [38], several reports describe the presence of AID mRNA transcripts in peripheral blood CLL cells [10],[12],[39] and high AID levels were associated with Richter's transformation, where CLL transforms into a highly aggressive B-cell lymphoma [40]. The gene discussed is AICDA; the disease is B-cell chronic lymphocytic leukemia.