A total of 11 genes involved in amino acid biosynthesis and metabolism were detected significantly (p < 0.05) reduced in both cirrhosis group, including amino acid biosynthesis genes (2-isopropylmalate synthase gene, cysteine synthase A gene, NADPH gene, L-threonine aldolase gene, prephenate dehydrogenase gene, serine O-acetyltransferase gene, valine-pyruvate aminotransferase gene, serine-tRNA ligase gene, and aspartate-ammonia ligase gene), and amino acid metabolism genes (glutamate decarboxylase A and B PLP-dependent gene, and lysine decarboxylase 1 gene). This evidence concerns the gene DECR1 and Cirrhosis.