TFPI2 and central nervous system cancer: It has been shown that TFPI-2 is down-regulated via epigenetic silencing mechanisms including promoter hypermethylation and histone deacetylation in several types of tumor, such as pancreatic ductal adenocarcinoma [28], melanoma [29], hepatocellular carcinoma [30], gastric carcinoma [31], and glioma [32].