These genes include Nkapl and Pde4b (both of which have been associated with schizophrenia; Kirsty Millar et al., 2005, Yue et al., 2011), Adcy5 (modulates dopaminergic transmission and can influence behavior and activity levels (Kim et al., 2008), Pmch (reported to act as a neurotransmitter and/or neuromodulator in goal directed behavior and arousal (Mul et al., 2011), and Cyfip2 (plays a role in establishing neuronal connectivity (Pittman et al., 2010). The gene discussed is PDE4B; the disease is schizophrenia.