Semiquantitative analysis showed a significant increase in hippocampal CD45 (two-tailed t test, young, **p = 0.001; aged, *p = 0.01, Figure 14A-C) and CD11b (two-tailed t test, young, **p = 0.0013; aged, *p = 0.02, Figure 14D-F) microglial markers in the brains of 3xTg-AD animals 12 hrs after CpG ODN i.p. administration in both age groups. This evidence concerns the gene ITGAM and Alzheimer disease.