TLR9 and Alzheimer disease: Stimulation of TLR9 signaling significantly decreased Aβ aggregates/oligomers in 3xTg-AD mice, in both study groups (7–20 month study group: one-tailed t test, *p = 0.03; 11–18 month study group: two-tailed t test, *p = 0.04, Figure 7C-D).