The index showed a good correlation with visceral fat deposition independent of BMI or subcutaneous adipose tissue accumulation.3 In this study, we observed the significant correlations between amino acid indices evaluating visceral fat obesity and insulin-related variables or adiponectin concentration, indicating the strong association among visceral fat deposition, insulin resistance and plasma amino acid profile. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.