IL4 and asthma: In vivo data showed that, the level of IL-4, a Th2 cytokine, in rAdV-CTLA4Ig and rAdV-CCR7-modified DC-treated mice decreased significantly compared to that of asthmatic mice, which is also consistent with our previous report that the DCs modified by rAdV-CTLA4Ig alone could also suppress IL-4 increasing in asthma mouse [8].