BBE can increase the mRNA expression of the genes G6Pase, GCK, and PEPCK relative to the glucose metabolism in liver and genes Ins1, Ins2, and PDX-1 relative to insulin secretion, which indicates that HuSang 32 mulberry BBE may regulate insulin secretion and reduce insulin resistance in STZ-diabetic mice. The gene discussed is PDX1; the disease is Insulin resistance.