One clinical research showed that circulating CTRP-3 concentrations were elevated in patients with T2DM and metabolic syndrome (MS) [8], while another one reported that serum and omental adipose tissue CTRP3 were lower in women with polycystic ovary syndrome (PCOS) and metformin treatment increased serum CTRP3 levels in these women and in omental adipose tissue explants [9]. The gene discussed is C1QTNF3; the disease is metabolic syndrome.