But the expression of CTRP3 at different stages of T2DM pathogenesis in human beings, the factors that modulates the expression of CTRP3 in the pathogenesis of T2DM and the mechanisms that GLP-1 receptor agonists modulate the expression of CTRP3 are still largely unknown and need further research. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.