CD8A and malaria: Instead, there is good evidence supporting cross-presentation of malaria antigens on CNS microvascular endothelial cells (Howland et al., 2013) and recognition by CD8+ cytotoxic lymphocytes leading to endothelial damage in a perforin- and granzyme B-dependant manner (Potter et al., 1999, 2006; Nitcheu et al., 2003; Haque et al., 2011).