Expression of these adhesion molecules on the cerebral microvascular endothelium has been reported in human and murine cerebral malaria (de Kossodo and Grau, 1993; Turner et al., 1994; Bauer et al., 2002; Armah et al., 2005) and ICAM-1 GKO mice are protected against PbA-induced cerebral malaria (Favre et al., 1999). The gene discussed is ICAM1; the disease is cerebral malaria.