In the present study, we demonstrated the IH induced aortic inflammation, as shown by increased expression of TNF-α and VACM-1 in the aortic tunica media after 8 weeks of IH, which was accompanied with increased expressions of markers of aortic oxidative stress (3-NT, 4-HNE), cell death, and remodeling (aorta tunica media thickness, collagen accumulation, and the expressions of CTGF and TGF-β1) in IH group. This evidence concerns the gene CUL5 and isolated hemihyperplasia.