INS and diabetes mellitus: This is exemplified by the study of Hansen et al., who induced insulin resistance and reduced glucose tolerance in healthy young males (without a family history of diabetes) after daily oral administration of 37.5 mg of prednisolone plus a high-calorie diet and physical inactivity during 12 days and observed a decrease in the incretin effect from 72 ± 5 to 43 ± 7%, while the insulin response to intravenous glucose was capable of completely compensate the impaired insulin sensitivity [28].