Interestingly, genes marked with these two histone modification marks include immunity related genes such as Toll, Immune Deficiency (IMD) and Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways; antimicrobial effectors such as defensins and cepropins; and metabolic genes such as the Vitellogenin gene. This evidence concerns the gene TLR4 and Immunodeficiency.