FTO and early-onset autosomal dominant Alzheimer disease: There is also evidence of other putative disease associations with FTO variants that have not achieved genome-wide significance, such as pancreatic cancer, Alzheimer's disease, attention deficit hyperactivity disorder, alcoholism, and osteoarthritis (Keller et al., 2011; Lurie et al., 2011; Sobczyk-Kopciol et al., 2011; arcOGEN Consortium et al., 2012; Corella et al., 2012; Reitz et al., 2012; Velders et al., 2012).