A UK study of 9103 individuals demonstrated the loss of association after adjustment for BMI, as the T2D-FTO association prior to adjustment for BMI showed an OR = 1.15, p = 9 × 10−6 and after adjustment showed an OR = 1.03, p = 0.44 (Frayling et al., 2007). This evidence concerns the gene FTO and type 2 diabetes mellitus.