Compare this sentence from the leptin paper, “Identification of ob now offers an entry point into the pathways that regulate adiposity and body weight and should provide a fuller understanding of the pathogenesis of obesity” (7), to words from the adiponectin reports, “We do not yet know the function of Acrp30” (6), “The role of the apM1 protein is not clear at present” (4), “The identification of adipo-Q [...] poses many questions regarding its molecular and biochemical properties that are yet to be examined” (3). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.