Consistent with this approach, viral-mediated overexpression of ALP components, such as transcription factor EB (TFEB), LAMP2a or Beclin-1, provided neuroprotection in viral-mediated α-syn-overexpressing rodent models of PD (Spencer et al., 2009; Decressac et al., 2013; Xilouri et al., 2013). Here, TFEB is linked to Parkinson disease.