PRKN and Parkinson disease: For instance, mutations in parkin (PARK2 locus), in the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) (PARK6 locus) or in DJ-1 (PARK7 locus), which are all involved in mitophagy, lead to autosomal recessive forms of PD (Corti et al., 2011).