In 1997, the first link between PD and α-syn was described with the identification of point mutations -A53T- in the SNCA gene in autosomal-dominant forms of PD (Polymeropoulos et al., 1997; Athanassiadou et al., 1999; Spira et al., 2001; Ki et al., 2007; Choi et al., 2008; Puschmann et al., 2009). Here, SNCA is linked to Parkinson disease.