However, PD-linked α-syn mutants (as well as post-translationally dopamine-modified wild-type α-syn) and mutant forms of LRRK2 block CMA activity, resulting in insufficient clearance and subsequent accumulation and aggregation of α-syn (Cuervo et al., 2004; Martinez-Vicente et al., 2008; Mak et al., 2010; Orenstein et al., 2013). Here, LRRK2 is linked to Parkinson disease.