IL6 and early-onset autosomal dominant Alzheimer disease: For example, elevated levels of IL-6 occur in the CNS or CSF of patients with clinical depression (Miller and O’Callaghan, 2005; Jones and Thomsen, 2013), active epilepsy (Billiau et al., 2007), Alzheimer’s disease (Brosseron et al., 2014), HIV infection (Gallo et al., 1989) and inflammatory neurological disorders (Wullschleger et al., 2013).