CDK5 and brain infarction: For example, our recent studies show that inhibition of RhoA/ROCK using Y27632 blocks the cascade of neurodegeneration triggered by cerebral infarction, prevents the deregulation of kinases involved in neuronal cytoskeletal remodeling, such as CDK5, favors synaptic connectivity and protects against cognitive deterioration (Castro-Alvarez et al., 2011).