This finding, in association with the finding that gene silencing of CDK5 decreased neuropathologic characteristics of neurodegeneration, such as neurofibrillary tangles (Piedrahita et al., 2010), may suggest that the use of RNAi-mediated suppression of CDK5 expression in astrocytes promotes the tripartite synapse and recovery from cognitive impartment after stroke. This evidence concerns the gene CDK5 and stroke disorder.