Based on the work of Plachta et al. (2007) one could expect gal-1 to be first upregulated in the TSCs of FF synapses in ALS as they are the first to shown signs of (morphological) damage during disease progression (Frey et al., 2000), potentially forming part of the molecular signature that gives these synapses their vulnerability to damage. The gene discussed is LGALS1; the disease is amyotrophic lateral sclerosis.