It has not yet been studied in the context of ALS, but given that satellite cells become activated after muscle injury or denervation (Seale and Rudnicki, 2000) and begin to express and secrete SEMA3A (Sato et al., 2013) it is possible that, upon disease-related denervation, satellite cells in an ALS muscle would also begin to produce SEMA3A. The gene discussed is SEMA3A; the disease is amyotrophic lateral sclerosis.