NOGO-A is highly expressed in skeletal muscle of presymptomatic ALS rodents and in clinical defined ALS patients and may even be a prognostic marker, its levels correlating with the severity of motor impairment as the disease progresses (Dupuis et al., 2002; Jokic et al., 2005; Pradat et al., 2007). This evidence concerns the gene RTN4 and amyotrophic lateral sclerosis.