Expression of asparagine synthetase (ASNS), which catalyzes the synthesis of asparagine, is negatively correlated with L-ASP’s anticancer activity in leukemia cell lines (Fine et al. 2005; Hutson et al. 1997; Scherf et al. 2000; Su et al. 2008), leukemia patient samples (Leslie et al. 2006), and ovarian cancer cell lines (La Spina et al. 2010; Lorenzi et al. 2006, 2008; Lorenzi and Weinstein 2009). The gene discussed is ASNS; the disease is leukemia.