In certain studies conducted in the Netherlands and Italy, it was shown that in breast and/or ovarian cancer patients who tested negative for BRCA1 or BRCA2 small mutations, about 20% carried an LGR in 1 of these 2 genes[5, 6], but many other studies reported a prevalence of under 10%[7, 8]. This evidence concerns the gene BRCA1 and ovarian carcinoma.