A novel anti-VEGF strategy by blocking its secretion in tumor cells is reported by retaining a VEGF binding protein in the cell (31), by inhibiting VEGF promoter activity on neuroendocrine tumor cell lines (32), by a PI3 kinase inhibitor in melanoma (33) and by IFN-α in melanoma cell line (34). The gene discussed is IFNA1; the disease is neoplasm.