PTGS2 and cancer: Previous reports suggested that NF-κB is an important transcription factor that regulates the expression of COX-2 and inflammatory cytokines[4, 29], the region of COX-2 gene promoter contains a binding sequence for NF-κB[30, 31], and transcriptional coactivator p300 can bind to promoter-bound transactivators such as NF-κB to regulate COX-2 gene expression in cancer cells.