Other OM-induced genes in this category were largely involved in inhibition of reactive oxygen species (ROS) (glutathione S-transferase and superoxide dismutase [Cu-Zn]), protein metabolism and processing (ribosomal protein, histone H3.2, subtilisin-like protease, serine-type carboxypeptidase, preprotein translocase subunit SecY), signaling (calmodulin-like protein 23, lectin, adhesive/proline-rich protein), cell wall modification (extensin class, beta-mannosidase 4, beta-tubulin) and cell defense and recue (class III chitinase, ATP synthase). The gene discussed is HPGDS; the disease is ocular melanoma.