TNF and T-cell non-Hodgkin lymphoma: Although anti-TNF biologics treatment are feared to increase the risk of malignancy particularly lymphoproliferative malignancy such as hepatosplenic T-cell lymphoma (HSTCL) which is the commonest reported subtype of all T-cell lymphoma, this phenomenon is still not yet confirmed in any published prospective cohort study [20, 28–33].