MYCN and neuroblastoma: The conformity with human neuroblastoma is further supported by the observation that genes, differentially expressed between high- and low-risk human neuroblastomas, either without or with inclusion of MYCN-amplified tumors, are more significantly altered in LSL-MYCN;Dbh-iCre tumors compared with normal adrenals from wild-type mice (Kolmogorov–Shmirnov test, P<0.001; Figure 5e).