Finally, one of the most strongly enriched gene sets among genes upregulated in the MYCN-driven tumors is the WHITEFORD_PEDIATRIC_ CANCER_MARKERS gene set, consisting of differentially expressed genes in a panel of xenografts representing eight common pediatric tumors (neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, acute lymphoblastic leukemia, Wilms' tumor, osteosarcoma, medulloblastoma and ependymona), compared with normal tissues12 (Figure 5a). Here, MYCN is linked to osteosarcoma.