The LSL-MYCN;Dbh-iCre signature, composed of the top 100 most differentially up- and downregulated genes in LSL-MYCN;Dbh-iCre tumors compared with normal adrenal gland, is significantly higher in neuroblastoma cell lines than in any other cancer cell line (Kruskal–Wallis rank sum test, P<0.001; Figure 5c). The gene discussed is MYCN; the disease is cancer.