TARDBP and amyotrophic lateral sclerosis: However, given that inclusions of poly(GP) proteins are present in some, but not all, affected regions of the central nervous system (CNS) in c9FTD/ALS [3, 20], and a recent study showing that poly(GA) pathology, unlike TDP-43 pathology, does not correlate with the degree of neurodegeneration in c9FTD/ALS [40], put into question the contribution of c9RAN proteins to disease pathogenesis.